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That's great that the treatment is working!!! As to why she is so tired, I think all of your ideas are right. Medication, chemo, worry, possible lack of nutrition could all be reasons she is tired. I promise ALL of us have been tired and fatigued - it's totally normal and to be expected. That will probably get better as she goes along. Does she have a desk job? If so, is it possible to have short walks or some type of mild exercise with you when she gets home? Exercise really does help with fatigue.
Plenty of us worked through treatment. Even though it's hard, it also can keep our mind off what else is happening.
By the way, one of the reasons this website exists is for people to be able to rant, rave, praise, cry, and ask questions. Feel free to do whatever you want!!!! We've ALL been there my friend.
Continued prayers for you and your wife.