The hope that curcumin would correct the trafficking defect of delF508 has not yet panned out in humans. However, what small amount of delF508 does reach your cell membranes can be somewhat stabilized by curcumin. The delF508 CFTR does not just have a trafficking defect--it also has problems with stability if it does get to the membrane. I figure we would help what little of our boys' delF508 does get out there to be more functional than otherwise!