Hi, Kim, actually our goal was to increase levels of circulating NO and not to improve poops. But improvement in poops was the only thing we could "look at" to see if we were raising NO levels and if that changed anything. Increases in NO are supposed to a) increase trafficking of delF508 CFTR to the cell membrane, b) increase the open time of delF508 mutant CFTR while at the membrane, and c) improve bactericidal activity of the immune system.