i guess brushing is the easiest. Missy doesn't NEED it, but she loves it! Chelsea finds it soothing. The hardest with Chelsea is eye drops and she hates it. She has become much better about ear drops, but if she sees the medicine before I can give it, she hides from me outside. Missy is really easy to pill because she will put anything in her mouth and she doesn't chew...she just swallows! LOL!