I have driven the I5 south from Vancouver through to Nogales border crossing and then down to La Manz several times. No problem.
A few minor caveats for the trip.
Get your Mexican Temporary Vehicle Permit online and delivered to your residence before you leave (Banjercito.com) and buy your Mexican vehicle insurance online.
At Nogales the border crossing is a "wave through" you must purchase your Visitor's permit and apply your Vehicle Permit at the 21 km checkpoint.
Don't go anywhere near Los Angeles -- the traffic is terrible. I head east about Bakersfield and aim for Wickenburg and then south to Phoenix.
It is about an 8 hour drive south from Mazatlan to Puerto Vallarta -- the first 4 hours there is a lack of gas stations and facilities -- fuel up in Mazatlan.
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