"Barnstable County Outbreak
Parks claims the Barnstable County Outbreak is proof the vaccines are ineffective in curbing transmission. I discussed the Barnstable County outbreak before:
Stock then brings up the Barnstable County outbreak and he gets applauded for some stupid reason, again ignoring context and misrepresenting data. We have no idea what the denominator for the outbreak described here was (i.e. how many people were exposed to the virus). There is no way to make a conclusion about vaccine effectiveness from that study, despite him trying to imply it shows the vaccine doesnít work. Hereís a thought experiment for you to understand why this isnít useful. Suppose I take 100 fully vaccinated people and put them in a room where I introduce aerosolized measles virus. We might expect a few of them to get sick because vaccines arenít 100% effective (2 doses of MMR-II are 97-99% effective against measles). 100% of the cases will be in people who were fully vaccinated. Does that mean the vaccines donít work? Secular trends in the incidence of measles would suggest otherwise. See this excellent animation by Dr. Kristen Panthagani in this post from Dr. Jeremy Faustís Inside Medicine Bulletin showing how breakthrough cases and disease prevalence change with vaccination rates. Provincetown has a 95% vaccination rate. If 74% of the cases were in vaccinated people, that gives vaccines (and this is across all 3 available in the US) 84% effectiveness (assuming everyone in Provincetown had equal likelihood of exposure) against symptomatic COVID-19 under conditions that would really stress test them. In short, this case series does not impugn the effectiveness of vaccines for COVID-19 and anyone claiming that it does either doesnít understand how vaccine effectiveness works or has an agenda.
There is no evidence that vaccinated individuals experience more severe COVID-19 either due to the delta variant or any other variant as a result of being vaccinated. It is still overwhelmingly unvaccinated individuals that experience the burden of severe disease in the US. I have discussed ADE specifically here. San Diego County for example has released a recent report on the burden of SARS-CoV-2 infections and how it splits among vaccinated vs. unvaccinated here. The unvaccinated are 4 times more likely to have a case of COVID-19, and 86 times more likely to be hospitalized due to COVID-19 than fully vaccinated people.
Variants and Immunity
Parks also claims that variants are so distinct from each other they are essentially different viruses. This is untrue. The ICTV has not even delineated different variants as being discrete strains, indicating a true difference in their properties. While antibody responses to the vaccines may vary some with different variants (although even then, the effect isnít particularly large), T cell responses remain largely invariant (pun not intended). In fact, even boosting vaccine recipients with the same vaccine for dose 3 shows substantial improvements in neutralization of variants of concern (Pfizer, Moderna)."