So easy for Nevada's seasoned remote-control drone operators to demolish an old hotel - a drone target so unusually close to the US - with a single Hellfire missile. Plausibly deniable too of course.
But probably better to have a few undercover ops plant/conceal remotely detonated explosives around the lower floors.

Memory refresher: IRA Brighton Hotel bombing 1984,Wikipedia etc:

"A long-delay time bomb was planted in the hotel by IRA member Patrick Magee with the purpose of killing Prime Minister Margaret Thatcher and her cabinet, who were staying at the hotel for the Conservative Party conference. Although Thatcher narrowly escaped the blast, five people connected with the Conservative Party were killed, including a sitting Conservative Member of Parliament, and 31 were injured."

https://en.m.wikipedia.org/wiki/Brighton_hotel_bombing
https://www.cbc.ca/archives/the-deadly-hotel-bombing-that-margaret-thatcher-survived-35-years-ago-1.5314562