Re: Call to Brits to take Vitamin D during lockdown Archived Message Posted by Mark Doran on April 23, 2020, 1:59 pm, in reply to "Call to Brits to take Vitamin D during lockdown" This is going to go the same way it always goes: people who 'don't like taking tablets' will kid themselves that they're going to get worthwhile vitamin D synthesis at these latitudes just by showing their face in daylight for a bit; and people who actually will take tablets will stick to ridiculously tiny doses too small to do the slightest good... For anyone interested in something meaningful... https://www.mayoclinicproceedings.org/article/S0025-6196(18)30313-6/fulltext To attain a blood level of 25(OH)D above 30 ng/mL requires adults to ingest at least 1500 to 2000 IU of vitamin D per day as recommended by the Endocrine Society’s practice guidelines on vitamin D.13 To achieve the preferred range in which the maximum benefit for reduced all-cause mortality has been observed,2, 7, 11 which is 40 to 60 ng/mL, would require 4000 to 6000 IU of vitamin D per day. For those who are obese, 2 to 3 times more supplementation is needed.7, 14 Ekwaru et al14 reported that adults taking up to 20,000 IU of vitamin D per day maintain blood levels of 25(OH)D in the range of 60 to 80 ng/mL and that such dosages of vitamin D were not attended by discernible toxicity. The Endocrine Society’s practice guidelines on vitamin D13 concluded that vitamin D toxicity is not observed until blood levels of 25(OH)D are greater than 150 ng/mL. Vitamin D toxicity, characterized by hypercalcemia, hyperphosphatemia, and suppression of parathyroid hormone, is usually observed when intakes are excessively high, in the range of more than 50,000 to 1 million IU of vitamin D per day and are maintained long-term for several months to years.7, 13 [...] There is no downside to increasing vitamin D intake and maintaining blood levels of 25(OH)D above 30 ng/mL unless there is an underlying vitamin D sensitivity associated with a granulomatous disorder, some lymphomas, and 25-hydroxyvitamin D-24-hydroxylase deficiency.7, 13 It has been found that at or above this level, maximum bone health is achieved.7, 13 Association studies have suggested that sensible sun exposure and increased vitamin D intake reduce the risk of autoimmune diseases, deadly cancers, infectious diseases, neurological dysfunction, cardiovascular disease, and type 2 diabetes that contributes to all-cause mortality.2, 7 Even nematodes live longer with vitamin D because vitamin D induces beneficial stress response genes and promotes protein homeostasis.16 The evidence for maintaining a blood level of 25(OH)D of at least 30 ng/mL for maximum bone health and reducing the risk of mortality from chronic illness is robust. --- May be worth mentioning that, rather than wait ages to gradually increase blood levels, you can front-load by starting with a week's worth all in one go. --- M. Message Thread: Call to Brits to take Vitamin D during lockdown - walter April 23, 2020, 1:28 pm Re: Call to Brits to take Vitamin D during lockdown - Mark Doran April 23, 2020, 1:59 pm I thought you were ... nm - Willem April 23, 2020, 3:10 pm   Searching