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    Re: Note on vaccines from BMJ Archived Message

    Posted by walter on May 13, 2020, 11:53 am, in reply to "Note on vaccines from BMJ"

    Well spotted Margo, thanks. I also found the note interesting.

    "Such an observation may seem counterintuitive, but it is possible that influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections; this has been observed with DTP and other vaccines. (Benn et al, Trends in Immunology, May 2013) There are other immune mechanisms that might also explain the observation."

    Expression of a certain amount of 'surprise' is seemingly in order. It is more than 'possible', it has indeed been observed many times; why would it then be counterintuitive?

    Skowronski: Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. https://www.ncbi.nlm.nih.gov/pubmed/20386731

    Due to these outcomes Skowronski later carried out an animal study in which the vaccinated animals also showed clinical H1N1 effects.
    https://www.ncbi.nlm.nih.gov/pubmed/24475142

    The adjuvanted H1N1 vaccine caused anaphylaxis in some people, admittedly a small number, but here, 20 times the normal reported rate for non-adjuvanted vaccines). These immune system effects need to be borne in mind as it's possible they should be game-changers.
    Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine,
    https://www.ncbi.nlm.nih.gov/pubmed/24144473


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