B12 Active or Inactive? Archived Message
Posted by Gerard on October 21, 2020, 10:26 am, in reply to "Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of...."
As a long time vegan (30 years or more), and an aloe vera distributor and cultivator (I have two in flower right now in my south facing bay window), I have a very special interest in this subject. Now-a-days B12 is added to many, many products...this is the "active" variety that actually replaces B12 otherwise found on/in meat or cheese. I say on/in because B12 is not (in essence), "naturally occurring" in/on meat or cheese, B12 occurs as a result of bacteria which live on same, if you buy a B12 supplement it will have come from a "cultured" source (it's all about the culture kiddies!). At one time aloe vera was (reputedly), thought to be the only plant to contain B12 but now it is thought that aloe vera is one of the plant sources of one of the inactive B12 analogues (go to: https://www.sunchlorellausa.com/blog/healthy-tips-4/post/chlorella-b12-active-form-v-inactive-vitamin-b12-2 for table of comparisons), quote; "Vitamin B12 is a coenzyme: it is needed for enzymes to do their job of changing one molecule into another. As vitamins go, B12 is large. One part of its structure is known as the corrin nucleus, which holds an atom of cobalt. The corrin resembles the heme of hemoglobin which holds an atom of iron. Any molecule that contains a corrin nucleus is considered a corrinoid. The corrin plus other atoms make up the cobalamin part of B12. There are many different cobalamins and they are named after their attachments. For example, methylcobalamin is cobalamin with a methyl group (one carbon and three hydrogens) attached. Only two cobalamins are active as coenzymes in the human body: adenosylcobalamin and methylcobalamin. The body has the ability to convert at least some other cobalamins into one of these active forms. Cyanocobalamin (a cyanide molecule attached to a cobalamin) is the form most often found in supplements and fortified foods because it is the most stable form of B12. The cyanide in cyanocobalamin is in amounts small enough not to be harmful to anyone except possibly those with cyanide metabolism defects—see Safety of Cyanocobalamin*. Most people readily convert cyanocobalamin into one of the B12 coenzymes (1). Hydroxocobalamin is also common in foods and the body; it can be converted into a B12 coenzyme. All corrinoids (including all cobalamins) are considered B12 analogues. Many corrinoids, and possibly even some cobalamins, are not usable by human B12 enzymes. These are considered inactive B12 analogues. In animal foods, B12 is protein-bound and partially light-protected (4). It is mostly in the form of adenosylcobalamin and hydroxocobalamin. In cow’s milk it is mainly adenosylcobalamin, but in dried milk it is mostly hydroxocobalamin with a trace of cyanocobalamin. Egg yolks and sardines contain a substantial proportion of methylcobalamin" Go to: https://veganhealth.org/vitamin-b12-analogues/ They also say, quote; " Patients with primarily neurological problems had significantly higher inactive B12 analogue levels (as shown by a difference between assays), than did patients with primarily blood problems. 33 of the 76 patients with neurological symptoms had a normal serum B12 when measured with R-protein. But when measured with intrinsic factor, many of these patients had much lower serum B12 levels. The R-protein assay was a reliable indicator of B12 deficiency in patients whose symptoms were primarily blood-related. This study indicates that some B12 analogues may be harmful to the nervous system or that some B12 analogues may have B12 activity in bone marrow (which produces blood cells) but not in the nervous tissue." IMHO the problems really come when one mixes active B12 with its analogues (a big problem for me now when utilising an aloe vera protocol -internally-, as I have to closely examine anything I eat for active B12 whilst the aloe is in my system). As we know B12 is the "happy vitamin" known as a serotonin precursor, I have found that B12 is so antagonistic to its anaolgues (and visa versa), that one can experience "brain-lock" similar to the mixing of incompatible entheogens such as Kava kava with cannabis or muscimol (quote; "Muscimol -also known as agarin or pantherine-, is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent, selective agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity."), with psilocybin (o.k once the body has had time to assimilate the muscimol for, as anyone who has taken significant doses of Amanita muscaria -mus-mus scarier!-, will tell you, the effects last for weeks as a mild amphetamine sulphate type "high" -"berserkers"?!-). As modern researchers are discovering (in Wicca such antagonisms are known as "breaches of the permissions"), blocking serotonin flow within the brain/cns is very bad medicine indeed (it's not good for the brain)! Quote; "The Abbott ARCHITECT Active-B12 assay is a test for detecting levels of serum holotranscobalamin, which is the metabolically available component of vitaminB12, and can be used as a marker of vitaminB12 deficiency. Four diagnostic test accuracy studies, using different reference standards, reported greater diagnostic accuracy for the Active-B12 assay compared with assays measuring other markers of vitaminB12 deficiency. The assay needs less sample preparation than a total vitaminB12 test and the expected cost is about £3.50 per test including VAT, depending on sample throughput." Go to: https://www.nice.org.uk/advice/mib40/resources/active-b12-assay-for-diagnosing-vitamin-b12-deficiency-pdf-63499159342789 *How strange that such an essential vitamin be so closely associated with a deadly poison.
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Message Thread:
- How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - dan October 19, 2020, 7:23 pm
- Telling... - Gerard October 19, 2020, 8:09 pm
- #FYI - Gerard October 19, 2020, 8:13 pm
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - Mary October 19, 2020, 9:00 pm
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - Mary October 19, 2020, 10:43 pm
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - dan October 20, 2020, 7:12 am
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - Tomski October 20, 2020, 8:01 am
- Good to hear you're on the mend (nm) - sashimi October 20, 2020, 8:50 am
- Nice one Dan, I hope they name a baseball bat after you....nm - Keith-264 October 20, 2020, 3:00 pm
- Glad you are on the mend. Thanks for all you do. NM - johnlilburne October 20, 2020, 3:32 pm
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - dereklane October 20, 2020, 3:47 pm
- Thanks all nm - dan October 20, 2020, 8:26 pm
- B12 Active or Inactive? - Gerard October 21, 2020, 10:26 am
- Re: How did we get in this mess? - almost certainly a bunch of bourgeois reformists but the graph of.... - ceemac666 October 19, 2020, 11:56 pm
- We got into this mess because all reactionaries can do is react. And that's if you're lucky .. - Shyaku October 20, 2020, 6:10 am
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