Re: Guardian: Plans for 30-minute Covid testing in England halted amid accuracy fears Archived Message
Posted by sotsog on December 26, 2020, 9:29 am, in reply to "Re: Guardian: Plans for 30-minute Covid testing in England halted amid accuracy fears"
I think this is one of the sources for that guardian article, the study paper is not yet written up. It also might be where you heard about the lateral flow test only finding 3% of positive people https://twitter.com/deeksj/status/1340975390412685312 Interestingly, from the same Twitter thread source: Our estimate of overall sensitivity is 3.2% (95% CI 0.6% to 15.6%). For cases with Ct<30 sensitivity it is 5.0% (95% CI: 0.8% to 32.1%) and <25 it is 100% (95% CI 15.8% to 100%) Someone has tweeted a reply: “Very interesting, as it highlights that increased ct returns more positive tests, PHE recommends a ct of 25.6, could you also not say that the 6 at increased ct could be false positives, were they confirmed real positives by other means?” Which is referring to the 6 pcr positives not found by the lateral flow test. ( Ct is the amplification) “The standard cutoff in the TurnKey lab is 35” that may be fine because systems vary, I don’t know. It’s impossible to conclude much from the above, due to too few numbers of positives, and you could never say that the lateral flow test is 100% sensitive when the Ct is below 25 based on 2 positive tests. I think it sort of highlights that there could be a somewhat circular argument when comparing one test with another. I mean if a better pcr test than the current best pcr test came along could it potentially “fail” in comparison?
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