I am just trying to understand the difference between assuming gsh or assuming nac.

I am starting with the considerations that inhaling GSH could't help because:

First, it is by definition difficult to access remore areas of the CF lung (especially those with mucus plugs in mid-size airways).

Second, GSH is stable only in acidic conditions and you do not want to inhale an acidic preparation (it is pro-inflammatory).

Third, GSH is highly reactive and if reaching oxidized regions, wil be instantly consumed and turned into its oxidized form GSSG (there is no known way to return this back into GSH in the extracelllular milieu).

On the other side we know that there is no problem with GSH synthesis in CF and we know that NAC is correctly synthesised by liver into GSH. Than we know that there is high consumption of gsh and assuming NAC it can feed the body with the necessary cysteine to make GSH and get it into blood neutrophils before they reach the lungs.

Just saying that, where is my error?

Thanks