Re: Doors of Perception? Archived Message Posted by Sinister Burt on April 28, 2020, 7:22 pm, in reply to "Re: Doors of Perception?" I'd love to know too, just in general. As i say, i go by David Nutt - there's no real evidence i know of (haven't looked in a while) of long term harm, just some evidence of slightly affected short term memory with heavy users (like cannabis). Notice in the chart Nutt puts mdma quite a way below cannabis (though probably mainly due to the smoking of it, rather than based on THC). Mdma pharmacologically is mostly like amphetamine in profile (which is also not all that physically bad for you in single controlled 'clinical' doses, hence approved use in adhd) - the methylene dioxy part (the md) makes the other end of the molecule slightly resemble a tryptamine (like psilocybin or serotonin), and so gives a slight serotonin agonism (it takes the place of serotonin at certain receptors (HT2x) - the same way other 'trip' tryptamines work), alongside the amphetamine's dopamine/serotonin release. It also releases oxytocin, thought to be linked to the empathy effect, though the mechanism for this wasn't fully understood (last time i was looking). Sorry, i'm probably telling you things you already know, but neuropharmacology is one of my amatuer interests so couldn't help meself. Message Thread: | This response ↓ soma holiday, anyone? - dan April 28, 2020, 7:38 am Twice-daily oral cannabis-oil doses certainly seem to help. And the one occasion when I happened on - Rhisiart Gwilym April 28, 2020, 8:13 am Re: soma holiday, anyone? - dereklane April 28, 2020, 8:47 am Re: soma holiday, anyone? - Mary April 28, 2020, 8:50 am Soma just riffing on a raga, it does something to me... - Subhi April 28, 2020, 9:27 am Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 9:18 am Re: soma holiday, anyone? - Dan April 28, 2020, 9:49 am Re: soma holiday, anyone? - dereklane April 28, 2020, 9:59 am Re: soma holiday, anyone? - Gerard April 28, 2020, 10:05 am Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 11:42 am Used to be known as "sassafras oil" - Gerard April 28, 2020, 6:40 pm Re: Used to be known as "sassafras oil" - Gerard April 28, 2020, 6:54 pm Re: soma holiday, anyone? - Gerard April 28, 2020, 6:45 pm Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 11:38 am Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 11:49 am last ride was in 1996 always liked it - Keith-264 April 28, 2020, 1:42 pm Re: last ride was in 1996 always liked it - Sinister Burt April 28, 2020, 4:48 pm E come alive!....nm - Keith-264 April 28, 2020, 7:59 pm Re: last ride was in 1996 always liked it - dan April 28, 2020, 11:43 pm Doors of Perception? - Gerard April 28, 2020, 9:58 am One for Keith 264 and any other lovers of early 90's deep house - Dan April 28, 2020, 10:05 am Eythenkew!....nm - Keith-264 April 28, 2020, 1:38 pm Re: Doors of Perception? - Sinister Burt April 28, 2020, 12:01 pm Re: Doors of Perception? - Gerard April 28, 2020, 6:31 pm Re: Doors of Perception? - Sinister Burt April 28, 2020, 7:22 pm Re: soma holiday, anyone? - brooks April 28, 2020, 10:40 am Re: soma holiday, anyone? - Gerard April 28, 2020, 10:53 am Re: soma holiday, anyone? - brooks April 28, 2020, 11:04 am Re: soma holiday, anyone? - Gerard April 28, 2020, 11:13 am Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 12:12 pm Re: soma holiday, anyone? - brooks April 28, 2020, 12:18 pm Re: soma holiday, anyone? - brooks April 28, 2020, 12:25 pm Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 4:54 pm Re: soma holiday, anyone? - Sinister Burt April 28, 2020, 12:31 pm   Searching